Research presented by Dr Erik Sahai has shown that early, reversible diversity in tumour cell state can blunt the effect of ...

Mitogen-Activated Protein Kinase (MAPK) signalling cascades are fundamental to the regulation of numerous cellular processes, including stress response, inflammation, cell cycle control and apoptosis.

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src ...

Cancer drug resistance is the devastating reason that treatments fail and cancers metastasize, spreading to distant sites ...

Few effective treatments exist to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 1 Existing treatments focus on ...

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint ...

The JAK2 gene is a protein-coding gene of the Janus kinase family. It plays a role in cellular signaling. Evidence notes connections between this gene and some medical conditions. Variations in this ...