Nat Clin Pract Neurol. 2008;4(3):159-169. Drug Primary clinical use Protective effect during administration in animal models? Effects of withdrawal in EAE Clinical study Phenytoin Treatment of ...

Thomas Kleyman, MD, professor of medicine and chief of the renal-electrolyte division at the University of Pittsburgh Medical Center, is a senior author of the study. Sodium channels found outside the ...

A novel, investigational NaV1.8 sodium channel blocker known as VX-548 reduced acute pain after abdominoplasty or bunionectomy at the highest dose, but not at lower doses, two phase II trials showed.

Note: On January 30, 2025 the FDA approved the first-in-class non-opioid analgesic Journavx (suzetrigine) for the treatment of moderate to severe acute pain in adults. The novel drug reduces pain by ...

Ion selectivity is an important property of cell membrane ion channels. For example, potassium ion channels are more permeable to potassium ions than to sodium ions. The mechanism underlying the ready ...

Managing sodium intake is crucial for individuals with chronic kidney disease because damaged kidneys may not effectively eliminate excess sodium, potentially leading to increased blood pressure and ...

In older adults, low sodium often results from certain medications, kidney issues, or infections. Because multiple factors may contribute, treatment depends on identifying the underlying cause. Sodium ...

A person living with chronic kidney disease (CKD) may need to take steps to reduce their sodium intake. This typically involves reducing the amount of salty foods they consume, as sodium is an element ...

A low sodium diet limits high sodium foods and beverages. Healthcare professionals typically recommend these diets to treat conditions such as high blood pressure or heart disease. Sodium is an ...