CDT1 overexpression suppresses DNA replication and triggers DNA damage linked to cancer, finds study

A research group has demonstrated that overexpression of Cdc10-dependent transcript 1 (CDT1), a key regulator of DNA ...

Alcohol-linked DNA damage tied to cancer risk: Study reveals repair enzyme's role

Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA. A research team from ...

Vital intertwining: Blood parasite's chainmail-like DNA structure could inspire next-generation materials

As tough as medieval chainmail armor and as soft as a contact lens. This material is not taken from science fiction, it is a ...

Uncovering the principle by which DNA replication initiation sites are determined in the human genome

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...
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New method reveals how human cells initiate DNA replication

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...
C&EN

New CRISPR-based tool targets DNA secondary structures with sequence specificity

Inside cells, DNA twists and coils itself into a variety of different secondary structures—including i-motifs (iMs) and ...

Scientists Solve a Decade-Old Mystery Behind Cancer’s Most Violent DNA Chaos

UC San Diego researchers uncover enzyme behind cancer genome chaos, pointing to potential therapies for aggressive tumors.