Morning Overview on MSN

Gut-liver serotonin pathway found to limit nanoparticle and viral delivery

Scientists at the University of Science and Technology of China have identified a signaling chain that starts with gut bacteria, triggers serotonin release from intestinal cells, and ends with liver ...

An immune signaling pathway drives pain in arthritis, researchers discover

Rheumatoid arthritis is a chronic autoimmune disease that affects millions of people worldwide. This disease prompts the ...

Curanex Expands Scientific Advisory Board With Two Distinguished Researchers

New Appointments Bring Deep Expertise in Immunology and Infectious Disease to Advance IND Submission and Intellectual Property StrategyJericho, ...

Intracellular signaling proteins emerge as a key target in drug development

In a recently published review, a research team led by MedUni Vienna has highlighted a promising new approach to drug discovery. The focus is on the targeted modulation of certain intracellular ...
The Hill

FDA proposes new treatment approval pathway for ultrarare diseases

The Food and Drug Administration (FDA) announced a new proposal Monday for flexible drug approval pathway treatments addressing ultrarare diseases. The FDA unveiled draft guidance on a proposed ...
STAT

FDA unveils rules for bespoke gene therapies, predicting flood of rare disease applications

Jason Mast is a general assignment reporter at STAT focused on the science behind new medicines and the systems and people that decide whether that science ever reaches patients. You can reach Jason ...
AFCEA

Clearing the Pathway for AI Cultivation

As artificial intelligence (AI) becomes increasingly crucial to military operations and winning the future fight, it is imperative that defense personnel identify and address factors that are ...
Scientific Research Publishing

Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., et al. (2020) Targeting Cancer Stem Cell Pathways for Cancer Therapy. Signal Transduction and Targeted Therapy, 5 ...

ABSTRACT: Meningiomas are common primary tumors of the central nervous system, affecting the intracranial and spinal dural surfaces. Multiple meningiomas account for approximately 1% to 10% of ...
Frontiers

Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems

Orexin receptors (OXRs), including OX1R (HCRTR1) and OX2R (HCRTR2), are G protein-coupled receptors (GPCRs) that are activated by endogenous orexin peptides (OXA and OXB) and have potential ...
EurekAlert!

Scientists reveal dual signal pathway that drives apple peel degreening

Fruit color transformation involves chlorophyll degradation, a key process determining ripening quality. Ethylene is known to trigger chlorophyll breakdown, while light can either promote synthesis or ...
eLife

Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

This study presents the important finding that lysosomal damage triggers inflammatory signaling through ubiquitination and the TAB-TAK1-IKK-NF-kB axis. The data obtained from the unbiased ...